A photoswitchable GPCR-based opsin for presynaptic inhibition

Copits BA*, Gowrishankar R, O’Neill PR, Li J, Girven KS, Yoo JJ, Meshik X, Parker KE, Spangler SM, Elerding AJ, Brown BJ, Shirley SE, Ma KKL, Vasquez AM, Stander MC, Kalyanaraman V, Vogt SK, Samineni VK, Patriarchi T, Tian L Sunahara RK, Gereau RW, and Bruchas MR* (*co-corresponding authors)

Neuron (2021) https://doi.org/10.1016/j.neuron.2021.04.026

Featured preview by He XJ and Banghart MR

Surgical implantation of battery-free optoelectronic epidural implants for optogenetic manipulation of spinal cord circuits

Grajales-Reyes JG, Copits BA, Lie F, Yu Y, Vogt SK, Banks AR, Rogers JA, Golden JP, and Gereau RW.

Nature Protocols (2021) https://doi.org/10.1038/s41596-021-00532-2

Cellular, circuit, and transcriptional framework for modulation of itch in the central amygdala

Samineni VK, Grajales-Reyes JG, Grajales-Reyes GE, Tycksen E, Copits BA, Pedersen C, Ankudey ES, Sackey JN, Sewell SB, Bruchas MR, Gereau RW 4th

eLife (2021) https://doi.org/10.7554/eLife.68130

Modeling features of addiction with an oral oxycodone self-administration paradigm

Murphy C, Chang YH, Pareta R, Li JN, Earnest T, Tooley J, Vachez YM, Gereau RW 4th, Copits BA, Kravitz AV, Creed MC.

BioRxiv (2021) https://doi.org/10.1101/2021.02.08.430180

Spatial transcriptomics reveals unique molecular fingerprints of human nociceptors

Tavares-Rerreira D, Shiers S, Ray PR, Wangzhou A, Jeevakumar V, Sankaranarayanan I, Chamessian A, Copits BA, Dougherty PM, Gereau RW, Burton MD, Dussor G, Price TJ

BioRxiv (2021) https://doi.org/10.1101/2021.02.06.430065


A paranigral VTA nociceptin circuit that constrains motivation for reward

Parker KE*, Pederson CE*, Gomez AM*, Spangler SM, Walicki MC, Feng SY, Stewart SL, Otis JM, Al-Hasani R, McCall JG, Sakers K, Bhatti DL, Copits BA, Gereau RW, Jhou T, Kash TJ, Dougherty JD, Stuber GD, and Bruchas MR (*equal contribution)

Cell (2019) https://doi.org/10.1016/j.cell.2019.06.034

Pain-induced negative affect is mediated by recruitment of the nucleus accumbens kappa opioid system

Massaly N, Copits BA, Wilson-Poe AR, Hipolito L,  Markovic T,  Liu S,  Walicki MC, Bhatti DL, Sirohi S, Walker BM, Neve R, Cahill CM, Shoghi K, Gereau RW, McCall JG, Al-Hasani R, Bruchas MR, and Moron JA

Neuron (2019) https://doi.org/10.1016/j.neuron.2019.02.029

A wireless closed-loop system for optogenetic peripheral neuromodulation

Mickle AD*, Won SM*, Noh KN*, Yoon J, Meacham KM, Xue Y, McIlvried LA, Copits BA, Samineni VK, Crawford KE, Kim DH, Srivastava P, Kim BH, Min S, Shiuan Y, Yun Y, Zhang J, Jang H, Li Y, Lai HH, Huang Y, Park SI, Rogers JA, and Gereau RW. (*equal contribution)

Nature (2019) https://doi.org/10.1038/s41586-018-0823-6


Angiotensin triggers painful macrophage-to-sensory neuron redox crosstalk

Shepherd AJ, Copits BA*, Mickle AD*, Kadunganattil S*, Tadinada SM, de Kloet AD, Samineni VK, Valtcheva MV, McIlvried L, Sheahan TS, Jain S, Ray PR, Usachev YM, Dussor G, Price TJ, Krause E, Gereau RW, and Mohapatra DP (*equal contribution)

The Journal of Neuroscience (2018) https://doi.org/10.1523/JNEUROSCI.3542-17.2018

Differential regulation of bladder pain and voiding function by sensory afferent populations revealed by selective optogenetic activation

DeBerry JJ*, Samineni VK*, Copits BA, Sullivan CJ, Vogt SK, Albers KM, Davis BM, and Gereau RW (*equal contribution)

Frontiers in Integrative Neuroscience (2018) https://doi.org/10.3389/fnint.2018.00005


Cadherin-10 maintains excitatory/inhibitory ratio through interactions with synaptic proteins

Smith KR, Jones KA, Kopeikina KJ, Burette AC, Copits BA, Yoon S, Forrest M, Fawcett-Patel JM, Hanley JG, Weinberg RJ, Swanson GT, and Penzes P

The Journal of Neuroscience (2017) 37(46)11127-11139; https://doi.org/10.1523/JNEUROSCI.1153-17.2017

N-glycan content modulates kainate receptor functional properties

Vernon CV, Copits BA, Stolz JR, Guzman YF, and Swanson GT

The Journal of Physiology (2017) 595(17):5913-5930; https://doi.org/10.1113/JP274790

Divergent modulation of nociception by glutamatergic and GABAergic neuronal subpopulations in the periaqueductal gray

Samineni VK, Grajales-Reyes JG, Copits BA, O’Brien DE, Trigg SL, Gomez AM, Bruchas MR, and Gereau RW

eNeuro (2017) 4(2):e0129; https://doi.org/10.1523/ENEURO.0129-16.2017

Complete disruption of the kainate receptor gene family results in corticostriatal dysfunction in mice

Xu J, Marshall JJ, Fernandes HB, Nomura T, Copits BA, Procissi D, Mori S, Wang L, Zhu Y, Swanson GT, and Contractor A

Cell Reports (2017) 18(8):1848-1857; https://doi.org/10.1016/j.celrep.2017.01.073


Spotlight on pain: optogenetic approaches for interrogating somatosensory circuits

Copits BA, Pullen MY, and Gereau RW

Pain (2016) 157(11):2424-2433; https://doi.org/10.1097/j.pain.0000000000000620

Surgical extraction of human dorsal root ganglia and preparation of primary cultures for functional studies of sensory neurons

Valtcheva MV*, Copits BA*, Davidson S, Sheahan TS, Pullen MY, McCall JG, Dikranian K, and Gereau RW (*equal contribution)

Nature Protocols (2016) 11(10):1877-88; https://doi.org/10.1038/nprot.2016.111

Group II mGluRs suppress hyperexcitability in mouse and human nociceptors

Davidson, S, Golden JP, Copits BA, Ray PR, Vogt SK, Valtcheva MV, Schmidt RE, Ghetti A, Price T, and Gereau RW

Pain (2016) 157(9):2081-8; https://doi.org/10.1097/j.pain.0000000000000621


Soft, stretchable, fully implantable miniaturized optoelectronic systems for wireless optogenetics

Park SI*, Brenner DS*, Shin G*, Morgan CD*, Copits BA, Chung HU, Pullen MY, Noh K, Davidson S, Oh SJ, Yoon J, Jang KI, Samineni VK, Norman M, Grajales-Reyes JG, Vogt SK, Sundaram SS, Wilson KM, Ha JS, Xu R, Pan T, Kim TI, Huang Y, Montana MC, Golden JP, Bruchas MR, Gereau RW, and Rogers JA (*equal contribution)

Nature Biotechnology (2015) 33(12)1280-1286; https://doi.org/10.1038/nbt.3415

Voluntary exercise training: analysis of mice in uninjured, inflammatory, and nerve-injured pain states

Sheahan TS, Copits BA, Golden JP, and Gereau RW

PLoS One (2015) 10(7):e0133191; https://doi.org/10.1371/journal.pone.0133191

Spatiotemporal control of opioid signaling and behavior

Siuda ER*, Copits BA*, Schmidt MJ*, Baird MA*, Al-Hasani R, Planer WJ, Funderburk SC, McCall JG, Gereau RW, and Bruchas MR (*equal contribution)

Neuron (2015) 86(4):923-35; https://doi.org/10.1016/j.neuron.2015.03.066


Human sensory neurons: membrane properties and sensitization by inflammatory mediators

Davidson S*, Copits BA*,  Zhang J, Page G, Ghetti A, and Gereau RW (*equal contribution)

Pain (2014) 155(9):1861-70; https://doi.org/10.1016/j.pain.2014.06.017

Modulation of ionotropic glutamate receptor function by vertebrate galectins

Copits BA, Vernon CG,  Sakai R, and Swanson GT

The Journal of Physiology (2014) 592(Pt10):2079-96; https://doi.org/10.1113/jphysiol.2013.269597


Isolation of novel prototype galectins from the marine ball sponge Cinachyrella sp. guided by their modulatory activity on mammalian glutamate-gated ion channels

Ueda T, Nakamura Y, Smith C, Copits BA, Inoue A, Ojima T, Matsunaga S, Swanson GT, and Sakai R

Glycobiology (2013) 23(4):412-25; https://doi.org/10.1093/glycob/cws165

Kainate receptor post-translational modifications differentially regulate association with 4.1N to control activity-dependent receptor endocytosis

Copits BA and Swanson GT

Journal of Biological Chemistry (2013) 288(13):8952-65; https://doi.org/10.1074/jbc.M112.440719

Lateral thinking: CaMKII uncouples kainate receptors from the mossy fibre synapse

Copits BA and Swanson GT

The EMBO Journal (2013) 32(4)287-289; https://doi.org/10.1038/emboj.2013.12

Commentary on: CaMKII‐dependent phosphorylation of GluK5 mediates plasticity of kainate receptors

A combined bioinformatics and chemoinformatics approach for developing asymmetric bivalent AMPA receptor positive allosteric modulators as neuroprotective agents

Chen H, Wang CZ, Ding C, Wild C, Copits BA, Swanson GT, Johnson KM, and Zhou J

ChemMedChem (2013) 8(2):226-30; https://doi.org/10.1002/cmdc.201200554

Afadin synchronizes dendritic structure and excitatory tone

Srivastava DP, Copits BA, Xie Z, Huda R, Cahill ME, VanLeeuwen J-E, Woolfrey KM, Rafalovich I, Jones KA, Swanson GT, and Penzes P

Journal of Biological Chemistry (2013) 287(43):35964-74; https://doi.org/10.1074/jbc.M112.363358


Dancing partners at the synapse: auxiliary subunits that shape kainate receptor functional properties

Copits BA and Swanson GT

Nature Reviews Neuroscience (2012) 13(10):675-86; https://doi.org/10.1038/nrn3335

Synaptic targeting and functional modulation of GluK1 kainate receptors by the auxiliary neuropilin and tolloid-like (Neto) proteins

Copits BA, Robbins JS, Frausto S, and Swanson GT

The Journal of Neuroscience (2011) 31:7334-7340; https://doi.org/10.1523/JNEUROSCI.0100-11.2011

Novel N-methylated 8-oxoisoguanines from Pacific sponges with diverse neuroactivities

Sakurada T, Gill MB, Frausto S, Copits BA, Noguchi K, Shimamoto K, Swanson GT, and Sakai R

Journal of Medicinal Chemistry (2010) 53:6089-99; https://doi.org/10.1021/jm100490m

High-affinity kainate receptor subunits are necessary for ionotropic but not metabotropic signaling

Fernandes HB, Catches JS, Petralia RS, Copits BA, Xu J, Russell TA, Swanson GT, and Contractor A

Neuron (2009) 63:818-829; https://doi.org/10.1016/j.neuron.2009.08.010